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Our salvaged blood filters are designed and validated to help protect patients from potentially harmful fat, leukocyte, and microaggregate contaminants in salvaged blood. As the effort to minimize the risks of blood product exposure has led to an increase in the use of autologous blood and cell salvage programs in many hospitals, autologous (especially salvaged) blood products need considerable processing before safe reinfusion can take place. We offer two salvaged blood filters to meet your needs:
Our salvaged filters help you mitigate adverse reactions to transfusions. With enhanced ease of use, minimal filter hold-up with high product recovery and increased filter life, this cost-effective solution can help improve your inventory management and minimize blood trauma.
Employing the heart-lung machine in cardiac surgery can lead to "pump lung." There is growing awareness of the etiology of this controllable adverse effect during cardiac surgery. In addition to leukocyte-mediated morbidity, fat globules have been associated with fat embolism syndrome that can manifest as pulmonary dysfunction. Some go on to suggest that fat globules may play a role in cerebral dysfunction that accompanies cardiac surgery.1 Leukocytes activated by the exposure of blood to the cardio-pulmonary bypass circuit may exacerbate lung damage when reperfusion of the ischemic lung at the end of surgery puts patients at risk for pulmonary dysfunction. Therefore, filters targeting fat globules and leukocytes may improve pulmonary function when used on salvaged blood destined for reinfusion.
Comparison Table for Leukocyte, Fat/Lipid and C3a Reduction
Both filters have small filter housings, priming is rapid. The tapered spike which is compatible with all conventional blood bags permits easy insertion and transfer from one bag to another during multiple unit transfusions.
Minimal filter hold-up volume with high product recovery
Low residual blood hold-up volume ensures the highest recovery of salvaged blood being transfused
Cost-effective patient blood management
Salvaged blood filters are part of a total leukocyte control strategy that is cost-effective in patients undergoing cardiopulmonary bypass surgery.2 In orthopedic surgery where fat embolism syndrome may occur, using filters to lower the fat burden in salvaged blood could be beneficial.
Orthopedic surgery and fat embolism syndrome
While fat embolism syndrome is likely an under-reported phenomenon associated with reinfusion of salvaged blood in cardiac patients, there is much greater sensitivity to the issue in orthopedic surgery.3 If you provide cell salvage services for these procedures, and use a bowl-based autotransfusion system, appreciate that fat particles are present in the washed salvaged blood, which can be significantly reduced by filtration.3
1 Brown W, Moody D, Challa V, Stump D and Hammon J. Longer duration of cardiopulmonary bypass is associated with greater numbers of cerebral microemboli. Stroke. 2000;31:707-13.
2 Gott JP, Cooper WA, Schmidt FE Jr, Brown WM 3rd, Wright CE, Merlino JD, Fortenberry JD, Clark WS, Guyton RA. Modifying risk for extracorporeal circulation: trial of four anti-inflammatory strategies. Ann Thorac Surg. 1998 Sep; 66(3):747-53.
3 Capan L, Miller SM, Pattel KP. Fat Embolism. Anesthesiology Clinics of North America 1993; 11:25-54.
For the Lipiguard® SB Reinfusion Filter for Salvaged Blood
Fat, leucocyte and C3a (and its immunosuppressive metabolite C3a des Arg77) were studied for both washed and unwashed salvaged blood, obtained intraoperatively and postoperatively, for the following procedures:
No statistically significant differences were found for the filter performance using either washed or unwashed, intraoperatively or postoperatively collected blood. Combined performance data is on file.
For the RS Leukocyte Reduction Filter for Intraoperatively Salvaged Washed Blood
White blood cells and fat globules were measured in intraoperatively salvaged blood prepared from patients undergoing cardiac surgery including coronary artery bypass procedures and valve replacements or repairs (n=14 [fat] and 15 [WBCs]). Pre- versus post-filtration values were analyzed using a paired t-test and the data are represented as means and standard errors. Results demonstrate significant reduction of both leukocytes and fat globules from salvaged blood. Performance data is on file.
LipiGuard™ SB Reinfusion Filter for Salvaged Blood
Leukocyte Reduction Filter for Intraoperatively Salvaged Washed Blood
Indications: The RS Leukocyte Reduction Filter is indicated for the transfusion of up to 2 bowls or 450 mL of intraoperatively salvaged, washed and concentrated autologous blood intended for reinfusion.
Precautions: Follow instructions carefully. Single use only; do not resterilize or reuse.
Do not use if packaging is damaged or end protectors are loose or displaced. Rx Only.
Note: This product is free of natural rubber latex.
The Pall LipiGuard SB Reinfusion Filter is a low priming volume blood filter designed for the reduction of fat particles, anaphylatoxin C3a microaggregates and leukocytes from up to 1 unit of washed or unwashed intraoperatively or postoperatively salvaged blood. The filter is indicated for the reinfusionof blood derived from the surgical site or postoperative wound drainage.
Sterilized by ethylene oxide.
STERILE and non-pyrogenic fluid pathway.
Precautions: Follow instructions carefully. For single use; do not resterilize or reuse. Do not use if packaging is damaged or end protectors are loose or displaced.
Pressure cuff: Use of this filter with a pressure cuff should comply with the recommendations of cell salvage equipment manufacturer's instructions for use.
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